I can't say whether it's all apps, but it's true of the ones I tried last night (I've since downgraded to .40).
I first noticed it running hg.exe from TortoiseHg, then tried unzip (from Info-Zip, not the builtin) and ncftp, then decided to downgrade.
Could the workarounds for Windows 8 & 10 bugs added to .43 be misbehaving on Windows 7?